ResearchPast Projects
TR37 - B5 - Magnetische Polymer-Nanopartikel

TR37 – B5 – Magnetic Polymer-Nanoparticle

Year:  2011
Funding:  German Research Foundation
Duration:  2007 - 2011
Is Finished:  yes

The project is divided into two main areas. The first focus is on research into the production of bioresorbable polymer-based nanovectors for the application of genes, proteins or even drugs. The second focus is on the development of microsystems with which magnetic nanoparticles can be specifically controlled. With the help of this targeted control, active substances coupled to the nanoparticles are to be introduced directly into the stem cell and trigger modifications there.

The IMPT develops, manufactures and characterizes an electromagnetic micro-pole-line (see Fig. 1 and 2). This pole line allows the targeted movement of nanoparticles or nanoparticle-polymer-gene complexes along the pole line to a stem cell positioned at the last pole of the pole line. Magnetically induced transfection at single cell level enables investigations into stem cell differentiation. Another future focus will be on the research and development of magnetic flux concentrators made of soft magnetic materials that can be integrated into implants such as pacemakers. These flow concentrators are designed to attract magnetic nanoparticles with coupled active substances in an externally applied supporting field so that they can be released locally into the tissue.